Overview:

This is one of a set of hypotheses we are considering involving a disruption in the blood brain barrier. See also BBB & Bacteria and BBB & Thyroid.

Background:

One of the ideas discussed as background to the other BBB hypotheses is that hypertension and/or changes related to the pregnancy may have triggered a disruption in the blood brain barrier, and that increased permeability is facilitating a seizure trigger. The hypotheses we are currently exploring involve bacteria and thyroxine as potential seizure triggers. There are a number of other triggers that could also be facilitated by a change in the permeability of the BBB.

Follow Up:

We are currently in the very early stages of researching other potential seizure triggers that would fall into this category. We are particularly interested in triggers with a bioperiodicity that would match the observed timing of the seizure clusters.

Questions:

We will be posting our questions in this area within the week, as we finish our initial review of the literature.

Action Plan:

No specific procedures or actions have been planned at this time, other than those outlined on the other BBB pages. See the BBB & Thyroid page for our consideration of statins as a treatment for reducing BBB permeability.

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