There have been a number of Lyme-related hypotheses proposed, based on the Applied Laboratory Services Culture which grew Borrelia Burgdorferi after 2 months and the IGeneX testing that suggests that the spirochete has been present for at least one year.


Conventional Lyme testing was negative (IgG, IgM) in 2011.

There are no Lyme related symptoms (e.g. arthritis).

Lyme treatment as of April 2012: Amoxicillin 1000mg bid; Azithromycin 500 mg q D.

Follow Up:

As we talk to various specialists, the Lyme disease diagnosis is controversial. At this point, it is being treated with antibiotics. However, it does lead to some raised eye-brows amongst non-Lyme physicians.

From our own review of the literature, we have been unable to find a case report of Lyme triggering seizures without the case being advanced and including evidence of severe demyelination on the scans.

We received the suggestio to specifically look at Bartonella Henselae, which has been shown to be transmitted by ticks and can be found in the cerebrospinal fluid of patients with symptoms of neuroborreliosis. There have been reports of meningitis and encephalitis secondary to Bartonella Henselae cerebrospinal fluid infection. However, this patients manifests no signs of meningitis or encephalitis. They further suggested investigating the more likely scenarios before pursuing Bartonella Henselae as the likely cause of this patients seizures. Mainly, because spinal fluid analysis from a lumbar puncture is the definitive test to determine if a patient has meningitis or encephalitis.

During a consultation with Dr. Stanton, a general practitioner, she noted that Lyme would not explain blood pressure spikes preceding the seizure clusters. She also noted that long term antibiotic treatment does not guarantee eliminating the spirochete.

One post on the FB page asked if we had tested for other tick-borne illnesses, such as Borrelia Hermsii, Babesia, Bartonella, Anaplasmosis, Ehrlichiosis, and Rocky Mountain Spotted Fever to name a few. This contributor further suggests considering treatment via IV Ceftriaxone, questioning whether Amoxicillan is effective in crossing the blood-brain barrier.

Another FB contributor aksed us to consult a physician trained in ILADS treatment.

We were also given a link to the following film: http://underourskin.com/


Is there some inflammatory/neuroexcitatory aspect of Lyme that could trigger seizures given the other underlying/ongoing conditions?

How likely is it that Lyme would trigger a seizure in the absence of evidence of demyelination?

Would Lyme (or another tick-borne illness) explain the timing/periodicity of the seizure clusters? For example, could the timing of the seizure clusters be tied to the spirochete life cycle?

Action Plan:

We are still in the process of considering what the next step would be to continue the evaluation of this hypothesis.

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